Ciência no Ecrã (Science on the Screen) é o novo Ciclo de Seminários Online do Departamento de Biologia, onde cientistas convidados falam de ciência e dão a conhecer os seus trabalhos de investigação em cerca de 30 minutos. A segunda temporada irá decorrer quinzenalmente, à segunda-feira, até ao final de março de 2021.
New approaches to study the aged synapse
Luísa Lopes - Instituto de Medicina Molecular (IMM)
22 Mar | 12:00 | videoconf link
Abstract
"While neuronal loss has long been considered as the main contributor to age-related cognitive decline, these alterations are currently attributed to gradual synaptic dysfunction driven by calcium dyshomeostasis and alterations in ionotropic/metabotropic receptors. I will share our data from humans and animal models that implicate adenosine A2A receptors (A2AR) upsurge as a crucial mediator of age-related synaptic dysfunction. Novel pathways implicate A2AR in the control of mGluR5-dependent NMDAR activation and subsequent Ca2+ dysfunction upon aging. In order to translate these mechanisms into human aging we are currently implementing novel models to study the synaptic signature of patient-derived neurons".
