WEDNESDAYS :: 12h :: VIDEOCONFERÊNCIA
2022
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13 de dezembro » Isabel João Silva - "Membrane transporter engineering for the optimization of microbial cell factoris"- CBMA - Centro de Biologia Molecular e Ambiental - Universidade do Minho Outline Current environmental concerns have driven the development of biorefineries for platform chemicals production, acting as alternatives to the chemical synthesis from petrochemical derivatives. Organic acids display great applicability in the polymer, food, agricultural and pharmaceutical sectors. Fermentation-derived carboxylic acids, e.g. succinic, lactic, and citric acid, are already commercially available however, the current portfolio is quite limited. One of the major bottlenecks for efficient and cost-effective bioproduction is molecule export through the microbial plasma membrane. In recent years, transporter engineering has been the focus of several studies, but the optimization of cell membrane transportes for industrial organic acid production is still at an early stage. This is due to the fact that the functional and structural characterization of membrane proteins is a cumbersome process. In our group, we tackle such challenges by uncovering novel plasma membrane transporter proteins to enhance the tolerance to carboxylic acids, increase production yields, and facilitate downstream processing. Transporter engineering strategies are focused on the improvement of transporter specificity, kinetics, and stability, to ultimately develop robust microbial cell factories for organic acid bioproduction. 12:00h | Auditório Mica |
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07 de dezembro » Jonatan Niño Sánchez - "Improving Spray-Inducing Gene Silencing (SIGS) technique by use of organic and inorganic nanoparticles"- Department of Plant Production and Forestal Resources - University of Valladolid Outline Fungal pathogens are responsible for many plant diseases and cause severe crop losses worldwide, threatening global food security. B. cinerea, the causal agent of grey mold disease on over 1000 plant species, can deliver small RNAs (sRNAs) to its host during the infection process to silence host defense genes, and the host plant is able to send sRNAs to the fungal pathogen to inhibit virulence genes. This mechanism was described by our group and called “cross-kingdom RNA interference”. The subsequent discovery that B. cinerea can efficiently take up environmental sRNAs that silence fungal genes with complementary sequences led to the development of an innovative and eco-friendly fungal disease management strategy: spray-induced gene silencing (SIGS). Although this spray application of RNAs is effective in controlling several fungal pathogens on pre- and post-harvest plant material, the durability of crop protection is not clear, because SIGS is limited by the stability of double-stranded RNA (dsRNA) and its uptake efficiency by the fungus. Here, we made use of nanotechnology to develop coated-dsRNA sprays against key virulence-related (Dicer-like, DCL1 and DCL2) and essential fungal growth genes (VPS51, SAC1, DCTN1) on various plant materials, including leaves, flowers and fruits. The use of nanotechnology provides dsRNA protection, as well as higher silencing efficacy than naked dsRNA application over time, therefore offering more potential and broader applications to control fungal plant diseases through sequence-specific SIGS technology. 12:00h | Auditório Mica |
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29 de novembro » Raquel Andrade - "Gene Expression Oscillations in Temporal Control of Embryo Development"- Universidade do Algarve Outline TIME is a difficult concept to grasp in Biology. However, cells seem to have no difficulty perceiving and decoding it over our lifetime. This is particularly evident during embryo development, when stem cell differentiation needs to occur at the right TIME and PLACE. An Embryo Clock (EC) operates in stem cell populations and consists of a network of genes that present oscillatory gene expression. The EC is conserved among vertebrates and was first described in the formation of somites – the precursor structures of the axial skeleton – as rhythmic cycles of gene expression of a hairy-enhancer-of-split transcription factor, hairy1 (hes4), in the chicken embryo. Although EC gene expression oscillations occur in multiple organisms, its functional role remains largely unknown. We aim to understand the functional role of EC oscillations in the stem cell-rich epiblast of the early embryo. Evidence will be presented suggesting that hairy1 oscillations drive the molecular programs in control of the anterior-posterior patterning of the vertebrate body plan. 12:00h | ZOOM | http://bit.ly/3goL2VF |
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24 de novembro » Célia Sousa - "Magnetic nanostructures for emerging medical applications"- Investigadora Sénior na Universidade Autonoma de Madrid, no âmbito da unidade curricular Temas Atuais em Biofísica e Bionanossistemas, do Mestrado em Biofísica e Bionanossistems Célia Sousa is specialized in nanoscience and nanotechnology and her interdisciplinary research has been mainly focused on the fabrication of nanostructures using self-assembling methods for biomedical and fuel cells technological applications. Célia Sousa has an h-factor of 28 (google academic)/25 (scopus/ISI) and published 74 papers in international peer review journals and with over 2440/1890citations (google academic)/(scopus). She published in Appl. Phys. Rev. (IF=17.1), Chem.Mater. (9.6), Nano Energy (16.5), Energy Environ. Sci. (33.2). 16:00h | ZOOM | https://videoconf-colibri.zoom.us/j/94894365504 |
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15 de novembro » Nuno Morais - "Finding molecular regulators of response to stress and senescence by intelligible analyses of transcriptomes"- iMM - Instituto de Medicina Molecular Outline In our Lab, we aim to understand how ageing-associated molecular changes in human tissues, namely at the transcriptional and RNA processing levels, increase proneness to disease. For that purpose, we apply mostly bioinformatic approaches to the analysis of phenotypically and clinically annotated high-throughput genomic and transcriptomic data. As computational biologists, we have the responsibility of making our ways of analysing data intelligible for, and therefore open for scrutiny by, collaborators and the entire scientific community, irrespective of their background. In this seminar, I will show how addressing our questions on the molecular aetiology of ageing, cancer and neurodegenerative diseases became concomitant with the development of tools for not only empowering colleagues to follow our analyses, but even equipping them with the necessary know-how to perform similar analyses themselves, while understanding the decisions involved at their every stage. I will also describe how this experience has leveraged our ongoing and future work on unveiling robust transcriptomic markers of cellular response to stress and, in particular, of senescence regulation. Such markers will allow us to revisit transcriptomes of human cells and tissues in physiological and pathological conditions, namely those related to ageing and associated diseases, profile stress and senescence and elucidate their role therein, while assessing their therapeutic targetability. They will also provide the community with a resource for similar studies in a myriad of other biological contexts 12:00h | ZOOM | https://videoconf-colibri.zoom.us/j/93173814720 |
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10 de novembro » Pedro Martins - Investigador Auxiliar do CBMA - "Multifunctional materials for environmental and antimicrobial applications"- Universidade do Minho, no âmbito da unidade curricular Temas Atuais em Biofisica e Bionanossistemas, do Mestrado em Biofísica e Bionanossistemas 10:00h Sumário: |
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3 de novembro » Florence Janody - "Using a humanized P-cadherin fly model to uncover key players involved in basal-like triple negative breast carcinomas"- i3S - Instituto de Investigação e Inovação em Saúde 12:00h | ZOOM | https://www.i3s.up.pt/personal-info.php?id=2117&idg=107 |
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18 de outubro » Isabel A. Abreu - "Calcium - dependente protein kinases as signal integrators and regulatory hubs of central metabolism"- ITQB NOVA 10:00h | ZOOM | https://videoconf-colibri.zoom.us/j/93173814720 |
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13 de outubro » Vasco Teixeira - "Nanomateriais e Nanotecnologia em Aplicações"- Departamento de Física, Universidade do Minho 10:00h | Sala edifício 1-2.08 | |
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4 de outubro » Martin B. Richards - "Ancient DNA at the edge of the wordl: Orkney and the archaeogenetics of Britan" - University of Huddersfield 12:00h | ZOOM | https://videoconf-colibri.zoom.us/j/93173814720 |
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20 de setembro » Miguel Prudêncio - "Pre-clinical and clinical evaluation of P. berghei based vaccine against human malaria" iMM - Instituto de Medicina Molecular João Lobo Antunes 12:00h | ZOOM | https://videoconf-colibri.zoom.us/j/93173814720 |
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13 de setembro » Vassiliki Iconomidou - "Functional and Pathological Amyloids and more: An Experimental and a Bioinformatics approach" National and Kapodistrian University of Athens 12:00h | Anfiteatro MICA do Departamento de Biologia |
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4 de abril » Maria Pia Cosma - "3D genome organization and looping in somatic and stem cellls" Center for Genomic Regulation (CRG) and ICREA, Barcelona, SpainEngineering 12:00h | videolink | ZOOM Meeting ID: 882 6655 5401 Password: 526606 |
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21 de março » António Vicente - "Tailoring food structures at nanoscale: from food-grade ingredients to actual safety concerns" CEB - Centre of Biological Engineering 12:00h | videolink | ZOOM Meeting ID: 882 6655 5401 Password: 526606 |
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7 de março » Andy Green - "Using breast cancer tissue in research" Nottingham Breast Cancer Research Centre 12:00h | videolink | ZOOM Meeting ID: 882 6655 5401 Password: 526606 |
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21 de fevereiro » Cláudia Nunes dos Santos - "Molecular Nutrition and Health Lab" CEDOC – CENTRO DE ESTUDOS DE DOENÇAS CRÓNICAS 12:00h | videolink | ZOOM Meeting ID: 882 6655 5401 Password: 526606 |
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7 de fevereiro » José Carlos Bessa - "Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancers" I3S Instituto de Investigação e Inovação em Saúde 12:00h | videolink | ZOOM Meeting ID: 882 6655 5401 Password: 526606 |
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24 de janeiro » Cidália Pina Vaz - "Anew AST assay for rapid sepsis diagnostic" Faculdade de Medicina, Universidade do Porto 12:00h | videolink Meeting ID: 882 6655 5401 Password: 526606 |
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10 de janeiro » Leonilde Moreira - "Within-host evolution of bacterial pathogens in the lungs of patients with cystic fibrosis" 12:00 h | videoconf link Meeting ID: 882 6655 5401 Password: 526606 |
