Departamento de Biologia - Universidade do Minho - Workshops e Seminários / Workshops and Seminars

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  18 de janeiro

» Ana Hortelão - "Enzime-Driven Nanobots: a journey from achieving nanoscale motion to in vivo translation in cancer therapeutics"

12:00 h | Aiditorium (5th floor) IB-S

  06 de fevereiro

»  Sonia Albillos Arenal - "Understanding recombinations between HXT6 and HXT7 in Saccharomyces wine strains and its influence on sugar transport" (Universidad of Valencia, Espanha)

12:00 h | Anfiteatro do Dep. Biologia

  20 de fevereiro

» Rüdiger Simon - "Regulation of plant stem cell niches" (Heinrich-Heine University, Alemanha)

» Resumo - Plant growth and development strongly depends on the activities of meristems, the plant stem cell niches, which can generate flowers, leaves or new branches. The number, size, position and identity of meristems ultimately determines a plant productivity, i.e. how many seeds a plant can generate or the size of its fruits. The last decades have allowed immense progress in our understanding of basic meristem activities, mostly with lab model plants such as Arabidopsis. Grasses like barley are important crop plants, and we are now starting to employ our knowledge on Arabidopsis stem cell systems to investigate and engineer barley architecture. In addition to this applied aspect, we found that technological innovations such as single cell RNA sequencing and gene editing, together with vast genome datasets allow us now to work with “difficult“ crop plants in a similar manner as we are used from the Arabidopsis model.“

12:00 h |Online  



  04 de março

» Andreas Thum - "From structure to function: what we can learn from the connectome of the Drosophila larva" (Departmant of Genetics, Leipzing University, Alemanha)

» Resumo"The Drosophila larva is a relatively simple, 10 000-neuron study case for learning and memory with enticing analytical power, combining genetic tractability, the availability of robust behavioral assays, the opportunity for single-cell transgenic manipulation, and an emerging synaptic connectome of its complete central nervous system. Indeed, although the insect mushroom body is a much-studied memory network, the connectome revealed that more than half of the classes of connection within the mushroom body had escaped attention. Further, it was found that activating individual dopaminergic mushroom body input neurons can have a rewarding or a punishing effect on olfactory stimuli associated with it, depending on the relative timing of this activation, and that larvae form molecularly dissociable short-term, long-term, and amnesia-resistant memories. Together, the larval mushroom body is a suitable study case to achieve a nuanced account of molecular function in a behaviorally meaningful memory network.”

Prof. Andreas Thum did his PhD at the University of Würzburg in the Department of Genetics and Neurobiology of Martin Heisenberg, where he studied the basis of learning and memory in adult Drosophila. In 2006 he moved to Fribourg (Switzerland) to the lab of Reini Stocker to analyze learning and memory in the fly larva. In 2011 he was awarded with an Emmy-Noether group, which allowed him to establish his own lab at the University of Konstanz. Since 2017, he has been a professor at the University of Leipzig, head of the Department of Genetics and, more recently, director of the Institute of Biology. His research group utilizes the Drosophila larva to identify the neuronal, molecular and behavioral basis of learning and memory.

12:00 h |ZOOM



  26 de março

» Irene Coin - Genetically encoded chemical tools for studying protein interactions in living cells" (Institute of Biochemistry, Leipzing University, Alemanha)

» Resumo"Modern methods for expansion of the genetic code have made it possible to incorporate artificial moieties into proteins as they are synthesized by the ribosomal machinery directly in the living cell, without the need of any chemical step. We apply genetically encoded non-canonical amino acids (ncAAs) to address general questions about functioning of G protein-coupled receptors (GPCRs) in the natural environment of the live mammalian cell. On one hand, we use photo-and chemical crosslinking amino acids [1] to define the topology of GPCR interactions both with ligands (especially peptide ligands) [2] and intracellular partners [3]. On the other hand, we have engineered enhanced tRNAs that have enabled efficient incorporation of last generation ncAAs for bioorthogonal chemistry into challenging protein targets [4]. In this way, we could achieve quantitative single-residue labeling of sensitive GPCR regions, such as the loops, with small organic fluorescent probes [5] and put the basis for the development of small-size fluorescent sensors for in-cell studies of GPCR dynamics.”

12:00 h |ZOOM


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